The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.
- Genre: Fantasy, Action, Adventure
- Studio: Laura Ziskin Productions, Marvel Studios
- Keyword: loss of loved one, dual identity, amnesia, sandstorm, love of one's life, forgiveness, spider, wretch, egomania, sand, narcism, hostility, sequel, superhero, based on comic, revenge, symbiote
- Cast: Tobey Maguire, Kirsten Dunst, James Franco, Thomas Haden Church, Topher Grace, Bryce Dallas Howard